None listed
Conditions
Interventions
This study is a prospective diagnostic proof of concept study to explore the diagnostic accuracy of MRDTI in the diagnostic management of acute and chronic SVT. This will be achieved by performing MRD
Sponsors
LUMC (Leids Universitair Medisch Centrum)
Eligibility
Inclusion criteria
Inclusion criteria: - Patients with confirmed acute SVT; definitions provided in paragraph 4.2 (Cases, group 1) - Patients with confirmed non-symptomatic chronic SVT, defined by incident SVT treated for at least 3 months and with chronic thrombi on 2 serial imaging tests with at least 3 months interval (controls, group 2) - Aged 18 years and older - Willing and able to give informed consent
Exclusion criteria
Exclusion criteria: - MRI contra-indication (including but not limited to a cardiac pacemaker or subcutaneous defibrillator; vascular clips in the cerebral vessels; metal splinter in the eye, a hearing aid that cannot be removed; a neurostimulator that cannot be removed; a hydrocephalus pump) - A medical condition, associated illness or co-morbid circumstances that precludes completion of the study procedures (MRI and 90-day follow-up assessment), including but not limited to life-expectancy less than 3 months, inability to lie flat, morbid obesity preventing use of MR and claustrophobia. - Patients with decompensated liver disease with ascites (since MRDTI evaluation will be inadequate in these patients)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To explore the diagnostic accuracy of MRDTI in the diagnostic management of acute and chronic SVT in a prospective diagnostic proof of concept study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To optimise MRDTI sequences for imaging SVT. 2) To assess the interobserver agreement of the readers of MRDTI for suspected SVT. | — |
Contacts
Public ContactLisette van Dam
Outcome results
None listed