atopic dermatitis atopic eczema wet-wrap therapy atopisch eczeem constitutioneel eczeem emollients
Conditions
Interventions
Wet-wrap therapy with diluted corticosteroid cream (mometason-furoaat with vaseline 20% cetomacrogolcream dilution 1:19 face and 1:3 body) vs. wet-wrap therapy with emollients (vaseline 20% cetomacrog
Sponsors
Charlotte van Sassen, KinderHaven, Havenziekenhuis Rotterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 6 months - 6 years at inclusion 2. Diagnosis of atopic dermatitis with an objective SCORAD > 40 3. Parent/legal guardian willing to comply with the protocol 4. Written, dated consent for subject to participate
Exclusion criteria
Exclusion criteria: 1. Known pre-existing, serious underlying disease 2. (Secondary) infected eczema: - In case of overt impetiginisation, wet wrapping should be delayed until 48-72 hours after commencing antibiotics and confirmation of appropriate treatment by skin swab results - Eczema herpeticum is an absolute contraindication for the use of wet dressings 3. Signs and symptoms of systemic infection (such as fever, defined as a temperature equivalent to a rectal temperature greater than 38.3ºC) 4. Problems in the hypothalamus-pituitary-adrenal (HPA) axis 5. Systemic corticosteroid therapy 6. Severe growth retardation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint concerns the comparison of the decrease of the objective SCORAD between the two groups for the various time points (=comparison of efficacy of the two therapies). | — |
Secondary
| Measure | Time frame |
|---|---|
| One secondary endpoint is the change of serum markers levels at various time points in the two groups and the correlation of the serum markers levels to the objective SCORAD (=development of an effective and objective value for monitoring the severity of AD) Another secondary endpoint is change in quality of life-score at the beginning and the end of the study in the two groups and the correlation of the quality of life score to the objective SCORAD and the serum markers. | — |
Contacts
Public ContactArnold P. Oranje
(Kinder)dermatologie Erasmus MC en KinderHaven, Rotterdam
Outcome results
None listed