Reproducibility of FDG PET scans in patients with lung cancer.

Test-retest reproducibility of whole body [18F]FDG PET-CT in patients with non-small cell lung cancer.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21780

Enrollment

Registered

2012-07-05

Start date

2012-08-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NSCLC Reproducibility FDG PET

Interventions

[18F]FDG PET at two seperate timepoints.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient age 18 years or older; 2. Histological diagnosis of NSCLC, stage IIIB or IV; 3. At least one tumour with diameter > 3cm (to minimize partial volume effects); 4. Able to remain supine for 60 minutes in the PET-CT scanner; 5. Written informed consent.

Exclusion criteria

Exclusion criteria: 1. Chemotherapy in the past 4 weeks; 2. Pregnant or lactating patients; 3. Metal implants (e.g. pacemakers); 4. Weight of more than 100 kg; 5. Known diabetes mellitus type I and II.

Design outcomes

Primary

Measure	Time frame
Reproducibility of various SUV measures, metabolic and anatomic volume measurements on whole body [18F]FDG PET-CT. Test-retest variability will be calculated and expressed in terms of intraclass correlations and Bland-Altman analysis. Two-sided paired t-test and correlation analysis will be performed to asses the significance of any differences in the outcome measurements (SUV and volume).	—

Secondary

Measure	Time frame
To evaluate reproducibility of the variables as a function of the [18F]FDG time uptake interval.	—

Contacts

Public ContactR. Boellaard

Department of Nuclear Medicine & PET Research VU University medical centre (VUmc) P.O. Box 7057

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)