Fasting Obesity
Conditions
Interventions
Fasting intervention: participants will undergo [123I]FP-CIT SPECT scans on two study days, prior to one study day participants will fast for 12 hours, prior to the other study day participants will f
Sponsors
Academic Medical Center (AMC), Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: - Male - BMI<25kg/m2 (lean subjects) or BMI ¡Ý 30kg/m2 (obese subjects) - Age 50-75 years - Stable weight three months prior to study inclusion
Exclusion criteria
Exclusion criteria: - Use of any medication except for those related to treatment of components of the metabolic syndrome - Use of exogenous insulin, oral glucose lowering drugs, beta-blockers - Any actual medical condition except for treated hypothyroidism and the metabolic syndrome - History of any psychiatric disorder - Shift work - Irregular sleep pattern - Intensive sports (>3 h/week) - Restrained eaters - History of eating disorders (anorexia, binge eating, bulimia) - Smoking, XTC, amphetamine or cocaine abuse - Alcohol abuse (>3 units/day) - Lactose intolerance - Estimated glomerular filtration rate <60 ml/min - Contraindication to MRI scanning (claustrophobia, metal foreign objects)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serotonin and dopamine transporter availability: [123I]FP-CIT SPECT scan | — |
Secondary
| Measure | Time frame |
|---|---|
| - Circulating hormones and substrates: venous blood drawing - REE: indirect calorimetry - Feeding behavior: validated questionnaires | — |
Contacts
Public ContactK.A. van Galen
Outcome results
None listed