familial combined hyperlipidemia
Conditions
Interventions
1. One day of venous lactate infusion and one day of saline infusion as a control, in healthy subjects and FCH patients
2. MRS scan of the brain will be done before the start of the infusion and at the end of the infusion.
Sponsors
Academic medical center
Eligibility
Inclusion criteria
Inclusion criteria: Healthy participants inclusion: 1. Male; 2. BMI 2.5 mmol/l; 6. No relevant active disease; 7. No known cardiovascular disease; 8. No statins intake for at least 6 weeks.
Exclusion criteria
Exclusion criteria: Medication influencing the brain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TG-VLDL synthesis by the liver measured by stable glycerol isotopes every hour. With the rate of disappearance curve synthesis will be calculated. | — |
Secondary
| Measure | Time frame |
|---|---|
| MRS changes in brain to define lactate levels in the brain. | — |
Contacts
Public ContactB.M. Sondermeijer
Outcome results
None listed