infection, sepsis, mitochondrial dysfunction
Conditions
Interventions
n/a
observational study
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: - Adult patients, aged between 18 and 85 years - Able to provide (deferred) informed consent themselves or informed consent can be obtained via next of kin or legal guardian - One or both of the following: o Clinical suspicion of a pulmonary or urinary tract infection o Fever (body temperature > 38.5°C)
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Discharged home without hospital admittance after ED visit - Congenital mitochondrial diseases - Renal transplant recipients - Hepatic failure (Child Pugh C) - Hepatorenal syndrome - Start of antibiotics before blood sampling
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of the current project is to study the association between biomarkers for renal mitochondrial damage in sepsis with the change in renal function and mortality after sepsis. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives of the current project are: - to study the association between biomarkers for renal mitochondrial damage in sepsis with the occurrence of cardiovascular events, co-morbidity, quality of life and functional status after sepsis. - to study the association between sepsis severity and the induction of renal and systemic mitochondrial damage. - to study the association between sepsis severity and the induction of renal and systemic DNA damage. - to study the association between systemic mitochondrial damage in sepsis with (change in) renal function, cardiovascular/renal risk factors, cardiovascular events, co-morbidity, quality of life, health/functional status and mortality after sepsis. - to study the association between sepsis severity and the (change in) renal function, cardiovascular/renal risk factors, cardiovascular events, co-morbidity, quality of life, functional status and mortality after sepsis. In addition, the following objectives will be studied in aged individuals (i.e. > 65 years old): - to study whether delirious patients demonstrate an aberrant functional status and number of circulating immune cells compared to patients that do not develop delirium following sepsis. - to study the association between peripheral cytokine levels and delirium following sepsis - to study the association between the occurrence of delirium during sepsis with the occurrence of cardiovascular events, co-morbidity, quality of life, functional status and mortality after sepsis. | — |
Contacts
Public ContactH.R. Bouma
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Outcome results
None listed