IMAGE trial: Intestinal Microbiota & Adipose Gene Expression.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21738

Enrollment

200

Registered

2010-05-25

Start date

2010-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gut microbiota, obesity, fat adipose tissue

Interventions

During the planned surgery visceral and subcutaneous biopsies will be obtained. In all patients venous blood samples will be taken and the patients will collect a feces sample.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy men and women, scheduled for elective laparoscopic cholecystectomy; 2. Age 18-85 yrs; 3. BMI 18-45 kg/m2.

Exclusion criteria

Exclusion criteria: 1. Generalized inflammation; 2. Antibiotic use last three months; 3. Malignant disease; 4. Metformin use.

Design outcomes

Primary

Measure	Time frame
Expression of genes in adipose tissue will be compared to gut microbiota composition.	—

Secondary

Measure	Time frame
We will try to relate regulation of genes to plasma markers of inflammation.	—

Contacts

Public ContactA. Vrieze

PO Box 22660

a.vrieze@amc.uva.nl+31 (0)20 5665983

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)