PET imaging of the noradrenaline system in healthy volunteers - a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21724

Enrollment

Registered

2019-08-01

Start date

2019-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pilot study: healthy volunteers only.

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Age = 50 years and < 80 years; willingness to cooperate and sign written informed consent.

Exclusion criteria

Exclusion criteria: Past or present developmental disorder or psychiatric disorder; abnormal results on the MMSE (<27); (subjective) memory complaints; presence of any contra-indication for PET scanning; participation in PET study in the last 12 months; use of any medication that acts on the NA system; absence of signed informed consent form.

Design outcomes

Primary

Measure	Time frame
From both the 90-min dynamic data and the 30-min static data, several values will be computed. These include NET binding potentials (BP), standardized uptake values (SUV) and K values for each region of interest (LC and projection areas), which will then be used to compute ratios using appropriate reference tissue models	—

Secondary

Measure	Time frame
Not applicable.	—

Contacts

Public ContactMaartje de Vries

University Medical Center Groningen

m.de.vries@umcg.nl0503614855

Outcome results