Reduction of oxidative stress in COPD by a combination of exercise and nutrition

The effect of nutritional supplementation as adjunct to exercise training on resting and exercise-induced oxidative stress, muscle function and exercise capacity in severe COPD patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21716

Enrollment

Registered

2007-07-12

Start date

2007-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, supplementation, antioxidants, rehabilitation COPD, supplementatie, antioxidatnen, revalidatie

Interventions

Nutritional supplement enriched with antioxidants vs. iso-caloric placebo

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosis of COPD according to the American Thoracic Society (ATS) GOLD guidelines (FEV1 < 60% predicted and FEV1/FVC < 70% and < 10% predicted improvement in FEV1 after b2-agonist inhalation (14, 15)); 2. Both male and female, age-range from 40 to 75 years; 3. No respiratory tract infection or exacerbation of the disease for at least 4 weeks before the study; 4. Capable to provide informed consent; 5. Presence of other chronic diseases is allowed in case the clinical status is stable for at least 4 weeks before the study.

Exclusion criteria

Exclusion criteria: 1. Inability to perform the incremental cycle ergometer test; 2. Chronic use of antioxidants or vitamin supplements; 3. Investigator's uncertainty about the willingness or ability of the patient to comply with the protocol requirements; 4. Participation in any other studies involving investigational or marketed products concomitantly or within two weeks prior to entry into the study; 5. Specific allergy or intolerance.

Design outcomes

Primary

Measure	Time frame
To asses the effect of daily ingestion of a nutritional supplement enriched with antioxidants during 8 weeks pulmonary rehabilitation on resting and exercise-induced oxidative stress in COPD patients compared to an iso-caloric placebo. Oxidative stress will be measured by specific biomarkers in exhaled air, breath condensate, urine and venous blood.	—

Secondary

Measure	Time frame
To examine the effects of daily ingestion of a nutritional supplement enriched with antioxidants during pulmonary rehabilitation on respiratory and skeletal muscle strength and exercise capacity in COPD patients.	—

Contacts

Public ContactEPA Rutten

Research, Development and Education Centre for Integrated Rehabilitation of Organ Failure (CIRO)

ericarutten@proteion.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)