schizophrenia apathy
Conditions
Interventions
None.
Sponsors
UMCG
Eligibility
Inclusion criteria
Inclusion criteria: Patients with schizophrenia (N=20): - At least 18 years of age - DSM-IV diagnosis of schizophrenia or schizoaffective disorder - Patient groups will be matched on age, sex, education, levels of depressive symptoms, medication and handedness - Written Informed Consent Healthy controls (N=10): - At least 18 years of age - Matched to patients on age, sex, education, levels of depressive symptoms and handedness Absence or low levels of apathy - Written Informed Consent
Exclusion criteria
Exclusion criteria: Patients with schizophrenia (N=20): Use of medication that can influence task results (e.g. beta-blockers, insulin) with the exception of antipsychotics Healthy controls (N=10): - Use of medication that can influence task results (e.g. beta-blockers, insulin) - High level of apathy - Presence of a psychiatric disorder, in present or past. All subjects (N=30): - Presence of a neurological or substance dependence disorder - Visual or hearing problems that cannot be corrected - Insufficient knowledge of the Dutch language - Inability to undergo cognitive testing Additional criteria, due to the use of neuroimaging (all subjects): - (Suspected) pregnancy - Claustrophobia - The refusal to be informed (by notifying the participant's physician) of structural brain abnormalities that could be detected during the experiment - MR incompatible implants in the body (such as ear prostheses or other metal implants) - Risk of having metal particles in the eyes - Tattoos containing red pigments that form a safety risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Binding potential for [11C]-raclopride. | — |
Secondary
| Measure | Time frame |
|---|---|
| endpoint MRI-scan PET-scan AES-C MINI-plus CDSS SANS AES-S SHAPS TEPS TCI FT N-back | — |
Contacts
Public ContactA. Aleman
Outcome results
None listed