Use of a PET scan to quantify disease activity in patients with hearing loss due to otosclerosis.

18F-fluoride PET scan as complementary diagnostic medium for patients with otosclerosis: A pilot study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21643

Enrollment

Registered

2010-10-29

Start date

2011-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Onderwerp: - Keel-, neus- en oorheelkunde - Otosclerose (fenestraal en cochleolabyrinthair) - PET/CT-beeldvorming Subject: - Otorhinolaryngology - Otosclerosis (fenestral and cochlear) - PET/CT imaging

Interventions

30 otosclerosis patients: 18F-fluoride PET scan of the head and neck with a low-dose CT scan for attenuation. Apart from that patients will undergo, or may already have undergone, a high-resolution CT

Eligibility

Inclusion criteria

Inclusion criteria: Study patients: 1. Fenestral otosclerosis; 2. Cochlear otosclerosis. Control patients: 1. Clinically relevant reason to undergo a PET/CT-scan with 18F-fluoride, in which the head & neck region is scanned as part of the protocol.

Exclusion criteria

Exclusion criteria: Otosclerosis patients: 1. Prior ear surgery at the concerning ear; 2. Chronic otitis media or chronic mastoiditis; 3. Tympanosclerosis diagnosed at prior ear surgery; 4. Claustrophobia or the inability to lie still during the scan; 5. Active malignancy; 6. Generalised bone condition (except osteoporosis); 7. Pregnancy or lactation. Control patients: 1. A history of ear surgery, with the exception of tympanic tubes; 2. Otosclerosis; 3. Generalised bone condition (except osteoporosis).

Design outcomes

Primary

Measure	Time frame
Semiquantitative measurements (SUV) of patients and control subjects at different areas areas of interest.	—

Secondary

Measure	Time frame
1. Disease activity compared to degree and course of hearing loss; 2. Disease activity compared to computed tomography findings.	—

Contacts

Public ContactJ.J. Waterval

Postbus 5800

J.Waterval@gmail.com+31 (0)43 3876543

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)