Onderzoek naar gedrag en hersenfuncties bij kinderen met een craniofaciale aandoening.

The neurocognitive functioning and behaviour of children aged six to twelve years with a syndromic or complex craniosynostosis.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21615

Enrollment

Registered

2011-05-27

Start date

2008-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Craniosynostosis is a congenital malformation characterized by premature closure of cranial sutures. The premature closure of the cranial sutures hinders the growth of the skull, brains and face. Craniosynostosis is 1 in 2500 newborns and is for approximately 40% of patients a part of a syndrome such as Apert syndrome, Crouzon / Pfeiffer, Saethre-Chotzen and Muenke. The treatment of syndromic or complex craniosynostosis craniofacial comprises a correction within the first year of life. Depending

Interventions

1. WISC-III-NL

2. ANT 2.1

3. FLANKER

4. n-BACK

5. TIME-TEST

6. SSRT

7. CBCL

8. DBD

9. i-DISC-IV

10. CCC-2.

Eligibility

Inclusion criteria

Inclusion criteria: All children receiving treatment at the Cranio-Facial Center ErasmusMC-Sophia with syndromic craniosynostosis (such as Apert syndrome, Crouzon/Pfeiffer syndrome, Muenke syndrome, Saethre-Chotzen syndrome) or a complex craniosynostosis and aged between 6 and 13 years.

Exclusion criteria

Exclusion criteria: 1. Children with syndromic craniosynostosis, whose parents master the Dutch language insufficiently to independently complete questionnaires; 2. Children familiar with one another syndromic abnormality.

Design outcomes

Primary

Measure	Time frame
Neuropsychological functioning as mentioned in the intervention box. Results on the questionnaires completed by the parents/cargivers.	—

Secondary

Measure	Time frame
Predictors: 1. Hypoplasia of the corpus callosum, septum pellucidum, hippocampus and cerebral cortex, white matter lesions and brain volume; 2. Ventriculomegaly, chronic tonsillar herniation, increased intracranial pressure, hydrocephalus and impressiones digitatae; 3. Obstructive sleep apnea syndrome (OSAS); 4. Genotype and diagnosis; 5. Age at first craniofacial correction and the type of correction, fronto-orbital advancement versus occipital expansion; 6. Socioeconomic status, child gender, child age.	—

Measure

Time frame

Predictors: 1. Hypoplasia of the corpus callosum, septum pellucidum, hippocampus and cerebral cortex, white matter lesions and brain volume; 2. Ventriculomegaly, chronic tonsillar herniation, increased intracranial pressure, hydrocephalus and impressiones digitatae; 3. Obstructive sleep apnea syndrome (OSAS); 4. Genotype and diagnosis; 5. Age at first craniofacial correction and the type of correction, fronto-orbital advancement versus occipital expansion; 6. Socioeconomic status, child gender, child age.

—

Contacts

Public ContactM. Maliepaard

Room sk 0156 Dr Molewaterplein 60

m.maliepaard@erasmusmc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)