Diabetes, obesity, insulin resistance,
Conditions
Interventions
None:
This is a comparitive study
10 obese men mached for gender and age with 10 lean men.
Sponsors
Academic Medical Center (AMC), Department of Endocrinology and Metabolism
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for all participants 1. Written informed consent 2. Caucasian 3. Able to keep a normal day and night rhythm during the study period (i.e. no shift work) 4. Stable weight for at least 3 months 5. Age 20-55 years Inclusion criteria for healthy volunteers: 1. 20 ¡Ü BMI ¡Ü 25 kg/m2 2. Fasting glucose level of 30 kg/m2 2. Fasting glucose level of 2.7
Exclusion criteria
Exclusion criteria: Exclusion criteria for all participants: 1. Participation in an investigational drug trial within 90 days prior to our study 2. history of or current abuse of drugs or alcohol (>14 U/week) 3. Smoking 4. Vigorous physical activity 5. Family history of DM II 6. Familial dyslipidemia 7. Any medical condition except hypertension and dyslipidemia in the obese group 8. Use of any medication except for anti-hypertensives, excluding ACE-inhibitors/AII-antagonists.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Peripheral glucose uptake (Rd) - Ganglisosides concentration in muscle and adipose tissue | — |
Secondary
| Measure | Time frame |
|---|---|
| - Plasma concentration of glucoregulatory hormones - Energy expenditure - Carbohydrate oxidation and fat oxidation - VO2 max - Muscle fiber type | — |
Contacts
Public ContactM. Brands
Academic Medical Center (AMC) F5-162 Endocrinology and Metabolism
Outcome results
None listed