Renal transplant recipients
Conditions
Interventions
All participants will undergo ultra-low-dose CT scanning and pulse wave velocity measurement in addition to the TransplantLines protocol.
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age ≥18 years 2. Male and female renal transplant recipients 3. Participant of TransplantLines 4. 6-12 months post kidney transplantation 5. eGFR > 30 ml/min/1.73m2 6. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. Life-expectancy < 2 years 2. Active malignancy; exception treated basal cell or squamous cell carcinoma 3. Known pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To validate serum calcification propensity as a read-out for change in vascular calcification, measured as CT-based coronary artery calcification score, in renal transplant recipients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identify determinants of vascular calcification (progression) in renal transplant recipients; classical cardiovascular risk factors, mineral metabolism factors, calcification inhibitors and dietary factors. | — |
Contacts
Public ContactN.T. Linde, van der
Outcome results
None listed