Gastro-enteritis caused by entero-invasive E. coli or Shigella species.
Conditions
Interventions
The intervention in the IBESS is a noninvasive single survey assessed by telephone for inquiry of epidemiological and clinical data of the patient. In case of a minor, one of the parents or caretakers
Sponsors
Centre for Infectious Disease Research, Diagnostics and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands ;
Certe Laboratory for Infectious Diseases, Groningen, The Netherlands;
Molecular Unit, Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Eligibility
Inclusion criteria
Inclusion criteria: Patients of all ages and sex who are 1) suffering from gastro-enteric complaints, and 2) Shigella or EIEC is detected in their feces sample by a IBESS participating medical microbiological laboratory during routine diagnostic procedures.
Exclusion criteria
Exclusion criteria: None, all patients that meet the inclusion criteria can be inclluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ƒ{The effects of the different diagnostic laboratory results on patient bound risk factors, incidence, spread, clinical relevance and economic consequences of infection. The severity of disease will be assessed with the use of the Modified Vesikari Scale (MVS), a validated gastroenteritis severity score for use in outpatient settings. ƒ{The effect of certain bacterial strain bound characteristics, both phenotypical and genotypical, on severity and spread of infection. The effects will be calculated with ordinal regression models, except for the effects of genotypical characteristics. For this, a bioinformatics approach is needed, and a pipeline of bioinformatics tools and a statistic approach will be developed during the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| ƒ{ Results of molecular epidemiology: the source and relatedness of Shigella and EIEC strains in the Netherlands. ƒ{ If applicable: recommendations for diagnostics to medical microbiological laboratories in the Netherlands. ƒ{ If applicable: recommendations about improvements of national guidelines for the realization and maintenance of quality management for control of infectious diseases caused by Shigella species or EIEC. | — |
Contacts
Public ContactMaaike J.C. van den Beld
RIVM
Outcome results
None listed