Cognitively normal adults with risk factors for cognitive decline
Conditions
Interventions
Participants are randomized in a 1:1 ratio to participate in either the high-intensity group or the low-intensity group for a duration of 24 months. The high-intensity multidomain lifestyle interventi
both online and at study site). The low-intensity intervention group gets online access to general lifestyle-related health information covering all domains except Souvenaid.
Sponsors
Amsterdam UMC, location VU Medical Center (VUmc)
Eligibility
Inclusion criteria
Inclusion criteria: 1. 60-79 years of age at pre-screening; 2. Adequate fluency in Dutch to understand the informed consent and complete questionnaires; 3. Providing informed consent to all study procedures; 4. Internet access at home; 5. Presence of =3 self-reported risk factors for cognitive decline (must contain at least 2 modifiable risk factors and 1 non-modifiable riskfactor):
Exclusion criteria
Exclusion criteria: 1. Diagnosis of dementia or mild cognitive impairment at baseline (self-reported); 2. Significant cognitive impairment assessed using the Modified Telephone Interview for Cognitive Status battery (TICSm score<23); 3. Conditions affecting safe and continuous engagement in the intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2-year change from baseline in global cognitive composite score derived from subtest scores from the Neuropsychological Test Battery (NTB) that includes 15-Word Verbal Learning Test delayed recall, DDST 90 seconds, WAIS digit span backwards, and animal fluency. | — |
Secondary
| Measure | Time frame |
|---|---|
| 2-year change from baseline in: a) individual cognitive test performances, representing memory, processing speed and attention and executive functioning; b) Instrumental activities of daily living; c) Quality of life; d) Modifiable dementia risk; e) Intervention specific outcomes f) Blood-based biomarkers for Alzheimer’s disease (Aß42/40, p-tau), axonal damage (NfL), astrocytes activity/injury or stress (GFAP) and brain plasticity (BDNF). | — |
Contacts
Public ContactMarissa Zwan
Amsterdam UMC
Outcome results
None listed