Cortisol Stress Expectations / Verwachtingen Placebo effects / Placebo effecten Nocebo effects / Nocebo effecten
Conditions
Interventions
For this study, participants will be allocated randomly to one of three conditions (placebo, nocebo, control). Conditions differ only with respect to a verbal suggestion that participants will receive
Sponsors
Health, Medical and Neuropsychology unit of Leiden University
Eligibility
Inclusion criteria
Inclusion criteria: Female and male healthy volunteers Between 18 and 35 years of age
Exclusion criteria
Exclusion criteria: Prior experiences with psychiatric or chronic somatic conditions affecting HPA-axis functioning Colorblindness Inability to speak Dutch Pregnancy Pacemaker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary cortisol (area under the curve from ground) based on four measurements (baseline, directly after stressor and 15 and 30 minutes after stressor) | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate and resulting heart rate variability Skin conductance Cognitive bias for positive and negative emotional words and emotional words overall (Emotional STROOP) after stress Salivary alpha-amylase Positive and negative affect assessed with PANAS Self-reported stress assessed with stress-related items on Visual Analogue Scales (VAS) | — |
Contacts
Public ContactJudith Tekampe
Health, Medical and Neuropsychology Unit, Leiden University
Outcome results
None listed