Omkering door TRH van opiaat-geïnduceerde ademdepressie en pijnstilling in gezonde vrijwilligers

Reversal through TRH of opioid-induced respiratory depression (OIRD) in healthy volunteers

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21474

Enrollment

Registered

2018-04-18

Start date

2018-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

opioid-induced respiratory depression

Interventions

TRH or placebo (intravenously)

Eligibility

Inclusion criteria

Inclusion criteria: - Healthy male or female volunteers; - Age: 18 - 40 years; - Body mass index < 30 kg/m2; - Able to give informed consent.

Exclusion criteria

Exclusion criteria: - Known or suspected neuromuscular or a (family) history of any neuromuscular disease; - A history of allergic reaction to food or medication including study medication; - Any current or previous medical (including high blood pressure), neurological or psychiatric illness (including a history of anxiety); - Alcohol abuse (> 21 units/week); - Illicit drug use in the past 30 days before inclusion; - Pregnancy or lactation; - Participation in any medical or drug trial in the month prior to the current study.

Design outcomes

Primary

Measure	Time frame
Respiratory measurements	—

Secondary

Measure	Time frame
Pharmacokinetics, side effects	—

Contacts

Public ContactM. Velzen, van

LUMC, Anesthesiology, P5 Albinusdreef 2

m.van_velzen@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)