Neonates suspected of infection, microbiome, antibiotic resistance
Conditions
Interventions
The three most common antibiotic strategies used in the Netherlands will be tested for side-effects on the microbial flora. A control Group will be composed of 44 vaginally born infants or infants bor
Sponsors
Linnaeus Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1. Need for empirical antibiotic treatment within the first week of life; 2. Vaginal birth or birth by emergency caesarean section; 3. Term delivery (defined as born after 36 weeks of gestational age).
Exclusion criteria
Exclusion criteria: Major known underlying disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To assess the short- and long-term prevalence of AMR genes in the microbiome of the gut in infants exposed to broad-spectrum antibiotics in the first week of life compared to controls. 2. To investigate the short- and long-term effects of broad-spectrum antibiotics administered in the first week of life on the composition of the microbiome of the gut in the first 5 years of life compared to controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify which of the recommended and generally used broad-spectrum antibiotic regimens for treating neonatal infections induces least AMR gene selection and disturbance of the microbial composition as compared to non-treated control neonates. | — |
Contacts
Public ContactMarta Reyman
Spaarne Gasthuis
Outcome results
None listed