Genetics of pelvic organ prolapse; identification of specific gene defects in patients and their family members.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21396

Enrollment

Registered

2009-08-05

Start date

2009-06-22

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pelvic floor, pelvic organ prolapse, genetic polymorphism, collagen

Interventions

None.

Eligibility

Inclusion criteria

Inclusion criteria: First and second degree relatives of patients with COL3A1 polymorphism.

Exclusion criteria

Exclusion criteria: 1. Genetic diseases with a known increased risk of POP (such as Ehlers Danlos, Marfan and Steinert’s disease); 2. Problems with regards to the patient’s understanding of the study; 3. Age < 18 years.

Design outcomes

Primary

Measure	Time frame
The presence of the COL3A1 polymorphism in first and second degree family members of the index patients with the homozygous COL3A1 polymorphism.	—

Secondary

Measure	Time frame
The presence of pelvic organ prolapse and related conditions (such as inguinal hernia) in first and second degree family members of the index patients with the homozygous COL3A1 polymorphism.	—

Contacts

Public ContactS.L. Lince

Universitair Medisch Centrum St. Radboud, Afdeling Verloskunde en Gynaecologie. Huispost 791. Postbus 9101

S.Lince@obgyn.umcn.nl.+31 (0)24-3614726

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)