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Localized epilepsy and neural networks.

Lesional epilepsy: the effects of surgical intervention on ictal onset zone and permissive neural networks.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON21379
Enrollment
40
Registered
2009-07-06
Start date
2009-07-09
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy Lesion Brain tumor Low grade glioma Mesiotemporal sclerosis MTS

Interventions

None listed

Sponsors

Dr J.C. Reijneveld, neurologist Department of Neurology - ZH 2F.35 VU University Medical Center PO Box 7057 1007 MB Amsterdam The Netherlands T +31 20 4442821 F +31 20 4442800 Email: JC.Reijneveld@vumc.nl Prof dr C.J. Stam, neurologist/neurophysiologist Department of Clinical Neurophysiology – PK -1Z.142 VU University Medical Centre PO Box 7057 1007 MB Amsterdam The Netherlands T +31 20 4440677 Email: CJ.Stam@vumc.nl Drs. H.E. Ronner, neurophysiologist Department of Clinical
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria for pharmacoresistant epilepsy patients are: 1. Adult ( 18 years); 2. Patients who undergo resective surgical treatment at the VUmc regarding the Dutch Collaborative Epilepsy Surgery Program; 3. Have given written informed consent. For brain tumour patients with epilepsy, inclusion criteria are: 1. Adult ( 18 years); 2. Patients who undergo resective surgical treatment of the tumour with epilepsy surgery techniques at the VUmc; 3. Are suffering from epilepsy which was not pre-existent to the lesion; 4. Have given written informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria are: 1. Psychiatric disease or symptoms; 2. Insufficient mastery of the Dutch language; 3. Inability to communicate adequately.

Design outcomes

Primary

MeasureTime frame
The main study parameters are a ECoG and MEG-based measures, assessing functional connectivity (SL and PLI) and neuronal brain networks (cluster coefficient and path length), seizure frequency and epilepsy burden.

Contacts

Public ContactE. Dellen, van

Postbus 7057

+31 (0)20-4444234

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)