Spinal cord injury Dwarslaesie Faecal incontinence Diarree Antibiotics Antibiotica Probiotics Probiotica
Conditions
Interventions
Participants will be randomly assigned to receive both an antibiotic treatment and Ecologic® AAD, or an antibiotic treatment and a placebo. Subjects will receive either probiotic or placebo for 26-31
5-10 days)
starting together with the antibiotic treatment and ending three weeks after cessation.
Sponsors
Heliomare Rehabiliation Wijk aan Zee
Reade Center for Rehabilitation and Rheumatology Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: - Confirmed diagnosis of SCI - First admission to a rehabilitation center after the occurrence of SCI. - Age between 18-75 years - Requiring treatment with antibiotics
Exclusion criteria
Exclusion criteria: - Known gastro-intestinal diseases - Abdominal surgery within a year prior to study - (Previous) radiotherapy or chemotherapy - Severe auto immune diseases such as SLE and Sjogren - Patients suffering from severe acute pancreatitis, multiple organ failure (MOF) or sepsis - Patients receiving enteral feeding with the exception of nasogastric feeding - Excessive alcohol intake (> 15 consumptions per week) - (Planned) pregnancy or lactation - Use of pre-, probiotics in the month before and during the study - Use of antibiotics in the two weeks before the study - More than one antibiotic treatment in the 6 month prior to the study. - Previous participation in this study design - Duration of antibiotics use longer than 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of faecal incontinence, defined by frequency, consistency, (un)wanted defecation, measured by the Bristol Stool Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life, nausea. | — |
Contacts
Public ContactMaaike Eken
Relweg 51
Outcome results
None listed