Providing diagnostic accuracy in acute onset, continuous dizziness.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21345

Enrollment

800

Registered

2021-01-12

Start date

2021-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute vestibular syndrome. Vertebrobasilar/cerebellar stroke. Peripheral vestibular syndrome.

Interventions

Not applicable.

Eligibility

Inclusion criteria

Inclusion criteria: - Acute onset, continuous dizziness, still present at arrival on the ED; - Presentation within 24 hours after onset of dizziness; - Age 18 years or older.

Exclusion criteria

Exclusion criteria: - Clear signs of benign paroxysmal positional vertigo (BPPV) (i.e. acute onset, continuous dizziness successfully treated by canalith repositioning); - A history of recognizable recurrent vertigo or acute onset, continuous dizziness compatible with Meniere’s disease or vestibular migraine; - Deficits upon neurological examination other than a nystagmus (i.e. ataxia (gait imbalance is allowed), dysarthria, spontaneous skew deviation, gaze palsy or lowered state of consciousness (i.e. EMV <14)); - Pregnancy at the time of inclusion; - Known contra-indication for MRI (e.g. claustrofobia, non MRI-compatible pacemaker or ICD); - Clear medical condition other than stroke (central) or non-stroke (peripheral) vestibular disorder that explains acute onset, continuous dizziness. Examples are hypotension, sepsis, medication related; - Previous inclusion in study; - No informed consent; - Unable to undergo follow up (e.g. life expectancy <3 months, severe cognitive impairment, no permanent residence in the Netherlands); - Insufficient command of the Dutch language.

Design outcomes

Primary

Measure	Time frame
Final diagnosis (stroke or peripheral) 3 months after inclusion.	—

Secondary

Measure	Time frame
- Healthcare costs (costs related to days of admission, costs of MRI/CT scans). - Resource use measurement during 3 months follow-up. - Quality Adjusted Life Years during 3 months follow-up. - Sensitivity/specificity of MRI DWI of the brain within 24 hours. - Sensitivity/specificity of MRI DWI of the brain after 72 hours. - Sensitivity/specificity of the “clinical gestalt” of the doctor. - Differences in sensitivity/specificity of the HINTS+ examination between neurologists/neurology residents and ED physicians/ED residents. - Incidence of acute onset, continuous dizziness (and proportion of stroke) in Dutch ED population.	—

Measure

Time frame

- Healthcare costs (costs related to days of admission, costs of MRI/CT scans). - Resource use measurement during 3 months follow-up. - Quality Adjusted Life Years during 3 months follow-up. - Sensitivity/specificity of MRI DWI of the brain within 24 hours. - Sensitivity/specificity of MRI DWI of the brain after 72 hours. - Sensitivity/specificity of the “clinical gestalt” of the doctor. - Differences in sensitivity/specificity of the HINTS+ examination between neurologists/neurology residents and ED physicians/ED residents. - Incidence of acute onset, continuous dizziness (and proportion of stroke) in Dutch ED population.

—

Contacts

Public ContactMerel Verhagen

Haaglanden Medisch Centrum

m.verhagen@haaglandenmc.nl088-9797900

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)