major depressive disorder bipolar disorder diagnosis fMRI
Conditions
Interventions
1. Questionnaire
2. Psychiatric interview
3. Affective neuropsychological testing
4. fMRI
5. Venapunction.
Sponsors
AMC
Eligibility
Inclusion criteria
Inclusion criteria: 1. Major depressive disorder (MDD) and Bipolar I and Bipolar II (BD I and BD II) patiens of both sexes; 2. Age 18-60 years; 3. Various levels of depressive symptomatology, ranging from moderate to severe (HDRS score at least 16); 4. At least 2 major depressive episodes, with remission between episodes; 5. Age of first episode younger than 40 years; 6. Illness duration of at least 5 years since first episode. In addition, for BD I and BD II: 7. At least one (hypo)manic episode (assessed by SCID) not solely during the use of antidepressants; Healthy controls (HC): 1. Age 20-60 years; 2. Euthymia at time of baseline (IDS less than 14).
Exclusion criteria
Exclusion criteria: MDD and BD I and BD II patients: 1. Electroconvulsive therapy within two months before scanning; 2. Current (hypo)mania (YMRS above 8; at study entry or within the previous month before baseline); 3. Atypical depressive symptomatology; 4. Concurrent comorbid axis I diagnosis; 5. A clear clinical diagnosis of cluster B personality disorder; 6. Currently using psychopharmacological medication (antidepressants, anticonvulsants or mood stabilizers stopped less than 2 months before scanning). Incidental benzodiazepine use will be allowed, but must be stopped before scanning. In addition, for MDD: 1. A history of (hypo)manic derailment after antidepressant use; 2. A family history of bipolar disorder. Healty Controls: 1. A lifetime psychiatric diagnosis (axis I, assessed by SCID); 2. A current diagnosis of alcohol or drug dependence; 3. First degree relatives with a history of psychiatric diagnosis; 4. Use of any psychopharmacological agent. All subjects: 1. A history of head trauma or neurological disease; 2. Severe general physical illness; 3. Claustrophobia or implanted metal. objects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will compare performance on the neuropsychological task between MDD, BD I and HC, measured by reponse time, number of omissions and number of errors. The same outcomes will be examined fot the neuroimaging tasks. We will compare brain responses of fMRI tasks relative to control conditions between MDD, BD and HC. We will compare responses in predefined ventral and dorsal brain regions (dorsolateral prefrontal cortex (PFC), ventral PFC, orbitofrontal, limbic and subcortical regions). | — |
Contacts
Public ContactM.M. Rive
Outcome results
None listed