sustained tocolysis, premature labour verlengde tocolyse, partus prematurus
Conditions
Interventions
Patients will be randomly allocated to nifedipine or placebo for 12 days
Sponsors
UMCN St Radboud, Nijmegen
Eligibility
Inclusion criteria
Inclusion criteria: 1. Gestational age between 26 and 32 weeks 2. Diagnosis of preterm birth 3. Treatment with tocolysis according to local protocol for 48 hours 4. Completed course of corticosteroids
Exclusion criteria
Exclusion criteria: 1. Signs of intrauterine infection 2. Signs of fetal distress 3. Maternal disease (ie. severe preeclampsia, HELLP syndrome)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Neonatal mortality - Composite neonatal morbidity (ie. chronic lung disease, severe intraventricular hemorrhage more than grade 2, periventricular leucomalacia more than grade 1, proven sepsis, necrotising enterocolitis) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Gestational age at delivery - Birth weight - Number of days in neonatal intensive care - Number of days on supported ventilation - Number of days on additional oxygen - Total days in hospital until 3 months corrected age - Economic analysis | — |
Contacts
Public ContactC. Roos
UMCN St Radboud Nijmegen Department of Obstetrics/ Gynaecology Postbus 9101
Outcome results
None listed