free fatty acid release vrije vetzuur afgifte
Conditions
Interventions
Propranolol infusion
Sponsors
Academic Medical Center (AMC), Department of Endocrinology and Metabolism
P.O. Box 22660
1100 DD
Amsterdam
The Netherlands
+31 (0)20 5669111
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male obese subjects (BMI > 30 kg/m2) and healthy lean controls (BMI 20 > 25 kg/m2) 2. Age 20 – 50 years 3. Stable weight 3 months prior to study inclusion 4. Caucasian 5. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Any chronic medical condition or use of any medication 2. Asthma and bronchospastic COPD 3. Tobacco use 4. Alcohol abuse (>3/day) 5. Frequent intensive exercise (>2 week) 6. Familial lipid disorders, renal insufficiency (creatinine > 150 umol/L) , elevated liver enzymes (> 2 times), hypertension 7. Hypotension (BP < 100/60 mmHg), bradycardia (HR < 60min) 8. Unwilling or unable to provide informed consent 9. First degree family members with diabetes 10. Abnormal day/night rhythm (shiftworkers etc) 11. Blood donation in the past three months
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| - Difference in nocturnal FFA levels between lean and obese subjects | — |
Primary
| Measure | Time frame |
|---|---|
| - Percent and/or absolute changes in nocturnal FFA levels with or without â-blockage. | — |
Contacts
Public ContactB.A.M. Weijer, de
Academic Medical Center (AMC) Department of Endocrinology and Metabolism P.O. Box 22660 1100 DD
Outcome results
None listed