Cohort of hepatitis B research in Amsterdam.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21330

Enrollment

172

Registered

2011-08-24

Start date

2011-04-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cirrhosis, hepatitis B virus, hepatocellular carcinoma, viral load

Interventions

1. Venapunction

2. Fibroscan

3. Health assessment questionnaire.

Eligibility

Inclusion criteria

Inclusion criteria: 1. HBsAg-positivity; 2. Serum sample available from the screening programme at the Public Health Service; 3. Still living and alive in Amsterdam or Diemen and address traceable by general practitioners or municipal authorities; 4. Non-Asian (both parents not born in Asia); 5. Between 18-65 years old; 6. Capable of giving informed consent and capable of traveling to the Public Health Service.

Exclusion criteria

Exclusion criteria: 1. Subjects coinfected with human immunodeficiency virus (HIV), hepatitis D virus (HDV) or hepatitis C virus (HCV); 2. Subjects who are unable to come to the outpatient clinic; 3. Subjects incapable to give informed consent due to legally incompetence.

Design outcomes

Primary

Measure	Time frame
Main study parameters are any of following complications: 1. Liver cirrhosis; 2. Death related to HBV morbidity.	—

Secondary

Measure	Time frame
Secondary study parameters are: 1. HCC; 2. Liver transplantation; 3. End-stage liver disease (Child-Pugh B or C); 4. Viral load of hepatitis B (comparison of historic and follow-up serum samples); 5. Parameters of activation, exhaustion and apoptosis in various subsets of immunological cells.	—

Contacts

Public ContactS. Harkisoen

P.O. Box 85500, F02.126

s.harkisoen@umcutrecht.nl+31 (0)88 7555555

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)