ECT for patients suffering from clozapine resistant schizophrenia

A single-blind, prospective, randomised, controlled study into the efficacy of electroconvulsive therapy (ECT) as treatment of clozapine-resistant schizophrenic patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21329

Enrollment

Registered

2008-04-22

Start date

2003-02-11

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psychosis, schizophrenia, clozapine, electroconvulsive therapy

Interventions

Clozapine vs. clozapine + ECT

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age: 18 yrs or older 2. Suffering from schizophrenia 3. Able to give informed consent 4. Treatment with clozapine for at least eight weeks with blood levels of at least 350 ng/ml has been shown to be inadequate 5. Inadequate treatment is defined as a score of at least 4 on 2 of the 4 psychotic items (paranoia, delusions, hallucinations, formal thought disorder) of the Brief Psychiatris Rating Scale (BPRS)

Exclusion criteria

Exclusion criteria: 1. Contra-indication for ECT: myocardial infarction less than 3 months old 2. Drugs or alcohol abuse less than a month ago 3. Clozapine blood levels higher than 1000 ng/ml

Design outcomes

Primary

Measure	Time frame
Positive symptoms score on the Positive and Negative syndrome scale (PANSS)	—

Secondary

Measure	Time frame
BPRS score	—

Contacts

Public ContactO. Nielsen

GP GGZ Delfland St Jorisweg 2

+31 (0)15 2607651

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)