Prostate cancer Prostaatkanker
Conditions
Interventions
nvt
Sponsors
PI: dr. I.J. de Jong, uroloog. UMCG
Eligibility
Inclusion criteria
Inclusion criteria: A prospective observational imaging pilot study. Only one point of measurement, where one scan will take place. Study population: 20 men with biochemical recurrent prostate cancer after radiotherapy who are candidates for local salvage treatment.
Exclusion criteria
Exclusion criteria: -Anti-androgen treatment in the last 6 months - other malignancies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - visual assessment of number of lesions en conclusion of re-staging (localized disease, systemic disease or a combination of the two) according to 18 F-FDHT PET/CT on patient-by-patient basis. - Semi-quantitative lesion assessment of tracer by measuring and evaluating the maximum and mean standardized uptake value (SUVmax, SUVmean) | — |
Secondary
| Measure | Time frame |
|---|---|
| Lesion-based analysis by comparing the detected lesions in different sites of recurrence/metastases with lesions detected by standard imaging by mMRI and PSMA PET/CT information from follow-up (PSA response to salvage therapy, confirmative biopsy or lymph node dissection and other imaging studies (X-ray, bone scans)). To assess overall accuracy, sensitivity, specificity, PPV and NPV. | — |
Contacts
Public ContactMarleen Vallinga
Hanzeplein 1 afdeling Urologie
Outcome results
None listed