General practice, Paediatrics, Acute gastroenteritis, Child, Cost-effectiveness, Antiemetic
Conditions
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 6 months to 6 years; 2. At least 24 hours with episodes of nonbilious, nonbloody vomiting; 3. At least one reported episode of vomiting within the four hours preceding presentation; 4. At least one episode of diarrhea during the period of illness; 5. Parental written informed consent.
Exclusion criteria
Exclusion criteria: 1. Requiring direct referral to an emergency department according to GP; 2. Use of anti-emetics in the previous 6 hours; 3. Known renal failure or hypoalbuminemia (as this could affect the assessment of hydration status); 4. Known diabetes mellitus or inflammatory bowel disease (as this could increse the risk of a complicated course); 5. A history of abdominal surgery; 6. Known sensitivity to 5-HT3 receptor antagonists; 7. Known prolonged QT-interval; 8. Current use of QT-prolonging medication; 9. Previous enrolment in the study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Cessation of vomiting, the number of vomiting episodes during ORT, intravenous rehydration, hospital admission rate and duration, healthcare use and costs. A vomiting episode will be recorded by the parent when a forceful expulsion of stomach contents occurs. Episodes separated by no more than two minutes will be counted as a single episode. Nonproductive retching, spilling of oral contents, and drooling are not considered vomiting. Cessation of vomiting will be noted at the time of a vomiting episode after which no more than 1 vomiting episode is noted during a period of at least 1 day. | — |
Primary
| Measure | Time frame |
|---|---|
| The proportion of referrals to a (paediatric) emergency department over a period of 5 days. | — |
Contacts
Public ContactY. Lisman-van Leeuwen
UMCG, afdeling huisartsgeneeskunde
Outcome results
None listed