Ventricular tachycardia, non-ischemic cardiomyopathy, catheter ablation.
Conditions
Interventions
The study will register:
• Baseline data including contrast enhanced MRI en echocardiography data.
• RFCA including induction protocol, electroanatomical maps, mapping and ablation strategy and acu
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: • age >18jr • sustained ventricular tachycardia within 6 months before enrolment • non-ischemic dominant left ventricular cardiomyopathy (dilated and/or systolic dysfunction) • accepted for radiofrequency catheter ablation of VT (intention to treat) • informed consent
Exclusion criteria
Exclusion criteria: • prior myocardial infarction • significant coronary artery disease (>75% stenosis in any major coronary artery) • right dominant cardiomyopathy • hypertrophic cardiomyopathy • LV non-compaction cardiomyopathy • restrictive cardiomyopathy • (sub)acute myocarditis • cardiac sarcoidosis • Chagas disease • tachycardia-induced cardiomyopathy • primary significant valve disease • congenital heart disease • prior valve replacement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint will be a composite of death and sustained VT recurrence as registered by ICD or surface electrocardiogram during follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Acute procedural success as determined by programmed electrical stimulation at the end of RFCA • Procedural complications • Burden of VT during follow-up • Type, localization and extend of myocardial fibrosis in relation to procedural success and VT recurrence | — |
Contacts
Public ContactA.P. Wijnmaalen
Outcome results
None listed