Sleep problems, in particular insomnia.
Conditions
Interventions
Acetaminophen versus placebo.
Acetaminophen will be given in a dosis of 1000 mg a day during two weeks. No medication will be taken in the first week.
Sponsors
Academic Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged ¡Ý 65 years; 2. Subjective sleep problems during > 1 month, at least once a week; 3. Patients must be willing and medically able to receive therapy according to the protocol for the duration of the study; 4. Patients must be able to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients using any acetaminophen on a regular basis (at least once a day) because of pain or who have an indication to start with it (VAS score > 6); 2. Patients who will be admitted to the hospital directly after the visit of the outpatient clinic; 3. MMSE 120 U/l, determined in the last six months; 7. Daily alcohol intake ¡Ý 4 units a day; 8. Suicidal tendencies to be assesed by the attending physician; 9. Participation in other trials concerning sleep.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint will be the self-reported sleep problems at the end of follow-up, measured by means of the Insomnia Severity Index (ISI). | — |
Secondary
| Measure | Time frame |
|---|---|
| In a subgroup of 15 patients we will measure the periods of wake and sleep with an actigraph during the three weeks of the study. | — |
Contacts
Public ContactE.M.M. Glind, van de
Postbus 22660
Outcome results
None listed