Obsessive-compulsive disorder
Conditions
Interventions
DBS targeted to the capsular area around the striatum. DBS consists of two phases: neurosurgical implantation of electrodes and an IPG, followed by optimization of electrical parameters of the pulses
Sponsors
Board of directors, Amsterdam UMC (location AMC)
Eligibility
Inclusion criteria
Inclusion criteria: 1) Obsessive compulsive disorder according to DSM-5 criteria; 2) At least one of the following conditions is met: a) Y-BOCS score = 25, b) Y-BOCS = 13 in case of solely obsessions or compulsions, or c) Suffering from obsessions or compulsions for at least 8 hours a day (i.e. a score of 4 on item 1 or item 6 of the Y-BOCS); 3) Treatment refractoriness as agreed upon by a multidisciplinary team of experts and consultation of an independent expert; 4) age must be 18 years or older; 5) mentally capable to understand the consequences of the procedure and make his or her own choice without coercion; 6) written informed consent.
Exclusion criteria
Exclusion criteria: 1) Primary diagnosis in psychotic spectrum; 2) Unstable multiple sclerosis (MS); 3) Acute brain damage (eg. recent hemorrhage or stroke); 4) General contraindications to have surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of responders after one year of treatment. Response is defined as =35% reduction of the Y-BOCS score compared to baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Decrease in Y-BOCS score over time; 2) number of reported adverse events; | — |
Contacts
Public ContactIsidoor Bergfeld
Academisch Medisch Centrum, Amsterdam
Outcome results
None listed