Migraine CGRP Propranolol Iontophoresis/Iontoforese Capsaicin/Capsaïcine
Conditions
Interventions
The volunteers will need to take a tablet of Propranolol 80mg (which is the normal therapeutic dose)
Sponsors
Dr. A.H. van den Meiracker,
Internist, Vascular Medicine.
Erasmus Medical Center Rotterdam
‘s Gravendijkwal 230, 3015GC Rotterdam, The Netherlands
Telephone number : 0031 010 7034220
Fax number : 0031 010 7034937
E-mail: a.vandenmeiracker@erasmusmc.nl
Eligibility
Inclusion criteria
Inclusion criteria: • Age between 18 and 64 years • Male or female • Females should use an oral contraceptive pill • Non-smoking for > 6 months • Body mass index between 19 and 30 kg/m2 • Capable and willing to give informed consent • General good health, based on medical history and physical examination
Exclusion criteria
Exclusion criteria: • History of cardiovascular disease • Blood pressure <110/70 (supine) • Heart rate <60 bpm • Perimenopausal status of females • Any serious illness that can compromise study participation • Use of any medication (e.g., NSAIDs, other analgesics) < 48 hrs before the study • Dermal diseases at the upper frontal side of the face • Pregnancy or breastfeeding • History of sensitivity to the fruits of capsicum plants (e.g. chilli peppers) • Alcohol or drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in dermal blood flow response to capsaicin application and saline iontophoresis, after propranolol administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure changes after propranolol use. | — |
Contacts
Public ContactJ. Langendonk
Erasmus Medical Center Rotterdam
Outcome results
None listed