The Pharmacology of Attention.

The neurobiological basis of bias and disengagement; Two neurotransmitter mechanisms implicated in visual spatial attention.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21222

Enrollment

Registered

2009-02-01

Start date

2009-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The neurobiology of attention.

Interventions

Pilot is a drug-free pilot aimed to verify results (ERPs / behavioral data) of previous studies, 12 participants will be included. The final study will contrast clonidine (0.1mg) and placebo. Like th

Eligibility

Inclusion criteria

Inclusion criteria: 1. Participants must be between 18 – 40 years old; 2. Passing the medical screening (in which cardiovascular functioning and blood pressure is evaluated) is a prerequisite.

Exclusion criteria

Exclusion criteria: 1. Use of any medication; 2. Low blood pressure, systolic bp under 100 mmHg, diastolic under 70 mmHg.

Design outcomes

Primary

Measure	Time frame
1. Behavioural measures; 2. In the Visual Spatial Cuing (VSC) paradigm: the validity effect in ms (RT valid cued target - RT invalid cued target). A larger validity effect reflects either more bias, or less disengagement; 3. In the stop task paradigm: the stop signal reaction time (SSRT); SSRT reflects inhibition and related disengagement; 4. Neurophysiological EEG (ERP) endparameters in the VSC: A. Parietal cue ERP components (ADAN + LDAP), related to bias; B. P1 valid cued target ERP, related to bias; C. LPD invalidly cued target ERP, related to disengagement. 5. Neurophysiological (ERP) endparameters in the stop task: A. N2 stop signal ERP, related to disengagement; B. LPD stop signal ERP, related to disengagement.	—

Measure

Time frame

1. Behavioural measures; 2. In the Visual Spatial Cuing (VSC) paradigm: the validity effect in ms (RT valid cued target - RT invalid cued target). A larger validity effect reflects either more bias, or less disengagement; 3. In the stop task paradigm: the stop signal reaction time (SSRT); SSRT reflects inhibition and related disengagement; 4. Neurophysiological EEG (ERP) endparameters in the VSC: A. Parietal cue ERP components (ADAN + LDAP), related to bias; B. P1 valid cued target ERP, related to bias; C. LPD invalidly cued target ERP, related to disengagement. 5. Neurophysiological (ERP) endparameters in the stop task: A. N2 stop signal ERP, related to disengagement; B. LPD stop signal ERP, related to disengagement.

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Contacts

Public ContactH.N.A. Logemann

H.N.A.Logemann@uu.nl+31 (0)30 2533386 / +31 (0)622233928

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)