Pulsatile II study.

Preservation of microcirculatory perfusion after pulsatile cardiopulmonary bypass: The role of prothrombogenic processes and the endothelium.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21204

Enrollment

Registered

2011-06-16

Start date

2011-06-20

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery bypass graft surgery, pulsatile cardiopulmonary bypass, microcirculatory perfusion, endothelial function, platelet aggregation, fibrinolysis

Interventions

Pulsatile cardiopulmonary bypass vs. non-pulsatile cardiopulmonary bypass.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing coronary artery bypass surgery (CABG); 2. Age 40-85 years; 3. Informed consent.

Exclusion criteria

Exclusion criteria: 1. Re-operations and emergency operations; 2. Patients with insulin-dependent diabetes mellitus; 3. Patients with a body mass index (BMI) > 35 kg/m2; 4. Patients with anemia (Hb < 5.5 mmol/l).

Design outcomes

Primary

Measure	Time frame
Change in microcirculatory perfusion during surgery, sublingual erythrocyte velocity, capillary diameter and capillary density.	—

Secondary

Measure	Time frame
1. Platelet aggregation; 2. Fibrin formation/degradation; 3. Red blood cell deformability; 4. Endothelial barrier function; 5. Endothelial biomarker expression.	—

Contacts

Public ContactChrista Boer

VU University Medical Center, Department of Anesthesiology

c.boer@vumc.nl+31 (0)20 4443830

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)