Effect of increased convective clearance by on-line hemodiafiltration on all cause and cardiovascular mortality in chronic hemodialysis patients. The Dutch CONvective TRAnsport STudy (CONTRAST).

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21199

Enrollment

800

Registered

2004-12-30

Start date

2004-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Patients will be randomised between: - online hemodiafiltration - (continuation with) low-flux hemodialysis

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients treated by HD 2 or 3 times a week, for at least 2 months; 2. Patients able to understand the study procedures; 3. Patients willing to provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. Current age younger than 18 years treatment by HDF or high flux HD in the preceding 6 months; 2. Severe incompliance life expectancy < 3 months due to non renal disease; 3. Participation to other clinical intervention trials evaluating cardiovascular outcome.

Design outcomes

Primary

Measure	Time frame
Cardiovascular morbidity and mortality. This is a composite endpoint comprising fatal and non-fatal myocardial infarction and stroke, and vascular death (death due to vascular disease). Also all-cause mortality is considered a primary endpoint.	—

Secondary

Measure	Time frame
Changes in carotid intima media thickness (cIMT), aortic pulse wave velocity (PWV), left ventricular mass index (LVMi), interdialytic blood pressure, laboratory assessments (oxidative stress; acute phase response; lipid profile; various), quality of life, and nutritional state.	—

Contacts

Public ContactE.L. Penne

University Medical Center Utrecht (UMCU), Department of Nephrology, Room F03.226, P.O. Box 85500

E.L.Penne@azu.nl+31 (0)30 2503063

Outcome results