Stroke, CVA, herseninfarct
Conditions
Interventions
Repeated remote ischaemic postconditioning (RIPostC): 4 cycles of ischaemia of the arm by inflating a blood pressure cuff around the upper arm at 20 mmHg above systolic blood pressure during 5 minutes
Sponsors
Radboudumc, Nijmegen
Eligibility
Inclusion criteria
Inclusion criteria: - Informed consent - Age >18 years - Clinically diagnosed ischaemic stroke using the WHO definition for stroke (“Stroke was defined as a rapidly evolving focal neurological deficit, without positive phenomena such as twitches, jerks or myoclonus, with no other than a vascular cause”).
Exclusion criteria
Exclusion criteria: Unstable vital signs Admitted >24 hours after onset of symptoms Upper extremity injury or edema contra-indicating remote ischaemic conditioning Mastectomy on both sides MRI contra-indications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To examine the impact of repeated daily remote ischaemic postconditioning, starting on the day of an ischaemic stroke on infarct size after 4 days or at the end of hospitalization (using MRI). | — |
Secondary
| Measure | Time frame |
|---|---|
| Explore the effect of repeated daily remote ischaemic postconditioning on clinical outcome after 12 weeks (using the modified ranking score; degree of disability/dependence). Assess the impact of repeated daily remote ischaemic postconditioning on validated and frequently used markers of vascular, immune, and anti-inflammatory pathways, and relate these effects to total infarct size and clinical outcome. | — |
Contacts
Public ContactT.R.J. Landman
Outcome results
None listed