chronic heart failure, sympathetic cardiac activity, 123I-MIBG
Conditions
Interventions
This is a prospective observational multicenter study.
Multivariate Cox proportional hazard regression analysis will be used to identify and evaluate risk factors associated with first occurrence of
Sponsors
Academic Medical Center, University of Amsterdam, the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Left ventricular dysfunction (LVEF ≤35%) due to prior MI; 2. Left ventricular dysfunction (LVEF ≤35%) due to non-ischemic heart disease; 3. NYHA functional class II and III; 4. Receiving chronic optimal medical therapy; 5. Reasonable expectation of survival with a good functional status of more than 1 year.
Exclusion criteria
Exclusion criteria: 1. NYHA functional class IV at enrollment; 2. Coronary revascularization within the preceding three months; 3. Myocardial infarction within 40 days prior to enrollment, as evidenced by measurement of cardiac-enzyme levels; 4. Advanced cerebrovascular disease; 5. Childbearing age and not using medically prescribed contraceptive measures; 6. Any condition other than cardiac disease that is associated with a high likelihood of death during the trial; 7. Unwilling to sign the consent form for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increased cardiac sympathetic activity and decreased sympathetic neuronal function as assessed by cardiac 123I-MIBG scintigraphy is associated with increased ICD discharge and anti-tachycardia pacing in patients with CHF and can therefore be used to identify patients who will most likely benefit from ICD implantation. | — |
Contacts
Public ContactHein J. Verberne
Department of Nuclear Medicine Academic Medical Center, F2-238 P.O. Box 22700
Outcome results
None listed