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Cardiac output, cerebral perfusion and cognition in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation

Cardiac output, cerebral perfusion and cognition in patients undergoing TAVI

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON21148
Enrollment
142
Registered
2020-06-19
Start date
2020-07-01
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aortic valve stenosis

Interventions

Transcatheter aortic valve implantation (TAVI)

Sponsors

This study is supported by grants from the Dutch Heart Foundation (CVON Heart Brain Connection 2012-06 & 2018-28), Dutch Federation of University Medical Centres, the Netherlands Organisation for Health Research and Development and the Royal Nederlands Academy of Sciences.
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Severe aortic valve stenosis (aortic valve area 18 years.

Exclusion criteria

Exclusion criteria: Presence of MRI contra-indication; inability to lay flat for 30 minutes; weight > 130 kg; neurological presence; active malignant disease; insufficient mastery of the Dutch language; alcohol use inability to withdraw 24 hours; non-atherosclerotic vascular disease (eg vasculitis).

Design outcomes

Primary

MeasureTime frame
Cardiac output (L/min), cerebral blood flow (mL/100g/min, change in %, relative to baseline) and cognitive functioning (extensive testing).—

Secondary

MeasureTime frame
Regional differences in changes in CBF after TAVI (? ml/min/m3); Identify patient and procedural characteristics associated with increased cardiac output, CBF, white matter hyperintensity volume and cognitive functioning ; incidence and volume of new white matter hyperintensities after TAVI (number and volume mm3, relative increase %); aortic valve calcification volume (mm3), measured with computed tomography.—

Contacts

Public ContactAstrid van Nieuwkerk

Amsterdam UMC, location AMC

a.vannieuwkerk@amsterdamumc.nl020 566603

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)