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A randomised clinical trial assessing the additional value of ovarian hyperstimulation in intrauterine insemination for couples with an abnormal post-coital test.

A randomised clinical trial assessing the additional value of ovarian hyperstimulation in intrauterine insemination for couples with an abnormal post-coital test.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON21145
Enrollment
250
Registered
2005-09-12
Start date
2002-06-01
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subfertility.

Interventions

These couples were randomly allocated to three cycles IUI with COH or three cycles IUI without COH. Controlled ovarian hyperstimulation as well as ovulation detection- induction, semen preparation an

Sponsors

OFO-project t.a.v. B.W. Mol Academic Medical Center Center of Reporductive medicine, H4-213 Postbus 22660 1100 DD Amsterdam Phone: 0031205663857 Fax: 0031206963489 e-mail: ofoproject@amc.uva.nl or b.mol1@chello.nl
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Couples were eligible if they had an abnormal PCT, either due to cervical hostility diagnosed by a well-timed, non-progressive PCT with normal semen parameters or due to a poor semen quality. The spontaneous pregnancy chance in the next year, leaving the result of the PCT out of consideration, was < 30%.

Exclusion criteria

Exclusion criteria: All other subfertile couples.

Design outcomes

Primary

MeasureTime frame
The primary endpoint was ongoing pregnancy within three cycles of IUI. Ongoing pregnancy was defined as the presence of foetal cardiac activity at transvaginal sonography at a gestational age of at least 12 weeks.

Secondary

MeasureTime frame
Secondary endpoints were total number of clinical pregnancies, miscarriages and multiple pregnancies.

Contacts

Public ContactP. Steures

Academic Medical Center (AMC), Center of Reproductive medicine, OFO-project, H4-213, P.O. Box 22660

pn.steures@amc.uva.nl / ofoproject@amc.uva.nl+31 (0)20 5663857

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)