Dysfunctional voiding: exploring disease transition from childhood to adulthood

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON21136

Enrollment

130

Registered

2021-05-04

Start date

2021-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dysfunctional voiding (DV) is a condition characterized by an impaired relaxation of the pelvic floor musculature during voiding, with a poorly understood etiology. In children and adults it is known to cause residual urine after voiding with subsequent UTI’s, and daytime urinary incontinence (DUI) due to an impaired sensation for the filling state of the bladder.

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in the study, a subject must meet all of the following criteria: 1. Female gender 2. Diagnosed with DV in childhood, defined according to the ICCS standardisation paper (3). 3. Completed follow-up (assessment of relief from infections and incontinence at 12 months after initial randomization) in the RCT of Klijn et al . Klijn AJ, Uiterwaal CSPM, Vijverberg MAW, Winkler PLH, Dik P, de Jong TPVM. Home Uroflowmetry Biofeedback in Behavioral Training for Dysfunctional Voiding in School-Age Children: A Randomized Controlled Study. J Urol. 2006;175(6):2263–8.

Exclusion criteria

Exclusion criteria: 1.Neurological bladder disorders

Design outcomes

Primary

Measure	Time frame
Persisting or relapse of DV from baseline and/or after conservative treatment to adulthood, expressed as the percentage of adults with DV. DV is herein determined according to ICS criteria as the presence of a staccato and/or intermittent urinary flow	—

Secondary

Measure	Time frame
- Daytime urinary incontinence in days per week, defined as any form of involuntary leakage of urine. - Post-void residual defined as the volume of urine in milliliter left in the bladder at the end of micturition. - Urinary tract infections , defined as a bacteriuria, with or without fever, with need for antibiotic treatment in the last six months. - Conservative treatment success, as described in the study of Klijn et al. (previous mentioned) and quantified according to the ICCS criteria.	—

Measure

Time frame

- Daytime urinary incontinence in days per week, defined as any form of involuntary leakage of urine. - Post-void residual defined as the volume of urine in milliliter left in the bladder at the end of micturition. - Urinary tract infections , defined as a bacteriuria, with or without fever, with need for antibiotic treatment in the last six months. - Conservative treatment success, as described in the study of Klijn et al. (previous mentioned) and quantified according to the ICCS criteria.

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Contacts

Public ContactNieuwhof-Leppink Anka

University Medical Center Utrecht/ Wilhelmina Children's Hospital

a.nieuwhof-leppink@umcutrecht.nl0623987959

Outcome results