Transfusion induced complications = transfusion associated complications ? study.

The effects of leukocyte filtered versus buffy coat depleted erythocyte transfusions in major surgery patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21130

Enrollment

1548

Registered

2005-09-09

Start date

2000-03-23

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The study population exists of major, non-cardiac surgery patients, who are expected to need > 3 units of red blood cell transfusions.

Interventions

Transfusions of filtered red blood cell concentrates vs. transfusion of stored buffy coat depleted red blood cell concentrates.

Eligibility

Inclusion criteria

Inclusion criteria: Acute aneurysm-, elective aneurysm-, orthopaedic- and large gastro-intestinal surgery patients.

Exclusion criteria

Exclusion criteria: 1. Under 18 years of age; 2. Transfusions received within 3 months prior to inclusion; 3. Pre existing medical indication for filtered red blood cell transfusions.

Design outcomes

Primary

Measure	Time frame
Postoperative: 1. In-hospital mortality; 2. Duration of intensive care stay.	—

Secondary

Measure	Time frame
1. Postoperative multi organ failure; 2. Postoperative infections; 3. Length of hospital stay; 4. Costs/benefits of universal leukocyte depletion for the Dutch health care; 5. Role of perioperative medication; Follow up 1. Long term survival; 2. Cancer recurrence in GI patients; 3. Predictive role of cytokines and related genes.	—

Contacts

Public ContactJ.A. Hilten, van

Sanquin Blood Supply Foundation, P.O. Box 2184

Joost.vanhilten@bloodrtd.nl+31 (0)71 5685060

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)