Asthma, COPD, subjects without airways hyperresponsiveness
Conditions
Interventions
Measurement of bronchial hyperresponsiveness with mannitol and methacholine.
Sponsors
Department of Respiratory Medicine
University Medical Center Groningen
Postbox 30.001
9700RB Groningen
the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: Asthmatics: 1. Episodic symptoms of dyspnea, and/or wheezing, and/or cough. 2. Allergic or non-allergic. 3. non current smokers (> 0.5 years). 4. PC20 MCh 40 yrs. 2. Active or former smokers, with a smoking history of more than 10 packyears. 3. Continuous symptoms of cough/sputum and/or dyspnea on exertion. 4. No history of asthma. 5. FEV1/FVC 8 mg/ml; 3. FEV1/FVC > 70 % and FEV1 > 90 %pred.
Exclusion criteria
Exclusion criteria: 1. Age 200, or diastolic BP > 100. 6. Known aortic aneurysm. 7. Pregnancy. 8. Nursing mothers. 9. Current use of cholinesterase inhibitor medication (for myasthenia gravis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time involved in measurement of hyperresponsiveness (including technician time for preparation and cleaning). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Patient reported adverse events. 2. Patient preference. 3. Technician preference. 4. Borg score during test. 5. Exhaled breath condensate (EBC). 6. Bronchial Hyperreactivity questionnaire (BHR, van der Molen 2005) | — |
Contacts
Public ContactE.D. Telenga
University Medical Center Groningen (UMCG), Department of Respiratory Medicine Hanzeplein 1 Postbox 30.001
Outcome results
None listed