Effects of high dose vitamin D suppletion on muscle mass and muscle strength in frail elderly peolple.

Effects of high dose vitamin D suppletion on muscle strength in frail elderly peolple.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21117

Enrollment

300

Registered

2007-02-26

Start date

2007-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypovitaminosis D Frailty Sarcopenia

Interventions

Individuals are randomized to recieve either 1200IU vitamin D/day and 1000mg calcium/day or placebo medications and 1000mg calcium/day. Medications will be used for a period of 6 months.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Frail elderly people, age > 65; 2. Living in homes for the elderly; 3. Serum vitamin D level < 50 nmol/l

Exclusion criteria

Exclusion criteria: 1. Not able to perform muscle strength measurements; 2. History of kidney stones, renal insufficiency (<40%); 3. Primary hyperparathyroidism; 4. Dementia (mini mental state examination < 20/30 points; 5. Life expectancy < 6 months; 6. Neurodegenerative disorders (M. Parkinson, ALS); 7. Use of the following medications: vitamin D, bisphosphonates, steroids.

Design outcomes

Primary

Measure	Time frame
Differences in muscle strength (handgrip strength and m. quadriceps strength) between treatment and control group	—

Secondary

Measure	Time frame
1. Changes in mobility a. Timed up & go test b. Walking distance 2. Quality of life a. Health assessment questionnaire 3. Falls	—

Contacts

Public ContactC. Oudshoorn

Erasmus MC PO box 2040 Room D442

c.oudshoorn@erasmusmc.nl010-4635037

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)