metabolic syndrome
Conditions
Interventions
intravenous infusion of acetate or saline
Sponsors
Amsterdam University Medical Centersm location AMC
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria healthy lean subject group: - Healthy Caucasian male or female - Age 40-65 - Women must be post-menopausal - BMI range of 19-25 kg/m2 - Subjects should be able and willing to give informed consent. Inclusion criteria obese metabolic syndrome subject group: - Caucasian male or female with metabolic syndrome - Age 40-65 - Women must be post-menopausal - BMI range of 25-40 kg/m2 - At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose = 5.6 mmol/L and/or HOMA-IR = 2.5, triglycerides = 1.6 mmol/L, waist-circumference > 102 cm, HDL cholesterol = 1.04 mmol/L, blood pressure = 130/85. - Subjects should be able and willing to give informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for all participants - Systemic medication use, except for paracetamol - Oral or intravenous antibiotics in the past 3 months before inclusion - Smoking - Substance abuse - Contra-indication for MRI, such as claustrophobia or pacemaker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main objective of this study is to look at the effect of iv acetate infusion on postprandial glucose metabolism and whether this effect differs between healthy lean subjects and obese subjects with metabolic syndrome. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives of this study are to study the effects of acetate infusion on postprandial lipid and SCFA metabolism, plasma glucagon-like peptide-1 (GLP-1) and ghrelin levels, subjective ratings of appetite and CNS regulation of appetite | — |
Contacts
Public ContactMax Nieuwdorp
AMC
Outcome results
None listed