Renal function after pulsatile blood flow during cardiopulmonary bypass in cardiac surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON21086

Enrollment

294

Registered

2014-10-06

Start date

2014-10-15

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac surgery

Interventions

Patients will be randomly assigned to the following study groups: - non-pulsatile bloodflow during CPB - pulsatile bloodflow during CPB Microcirculatory perfusion will be measured sublingually with

Eligibility

Inclusion criteria

Inclusion criteria: Adult subjects with written informed consent (age 18-90 years) undergoing elective cardiac surgery with cardiopulmonary bypass; Patients with preoperative renal dysfunction (GFR <50 mL/min/1.73m2) or patients with diabetes mellitus and a GFR <60 mL/min/1.73m2 based on the CKD-EPI formula.

Exclusion criteria

Exclusion criteria: - Emergency operations; - Patients with previous heart surgery; - Renal failure requiring preoperative renal replacement therapy (RRT)

Design outcomes

Primary

Measure	Time frame
Relative change in serum creatinine levels in postoperative period	—

Secondary

Measure	Time frame
Postoperative urine production in ml; Serum urea levels, creatinine clearance, glomerular filtration rate; Nadir DO2, DO2/VCO2 ratio; Sublingual microcirculatory perfused vessel density and perfused boundary region (n=40); Microcirculatory and tissue oxygenation O2C levels (n=40); Prevalence of renal replacement therapy	—

Contacts

Public ContactChrista Boer

VU University Medical Center, Department of Anesthesiology

c.boer@vumc.nl+31 (0)20 4443830

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)