Critically ill patients requiring continuous intravenous sedation.
Conditions
Interventions
Patients will be randomised to one of the following three arms of the trial:
1. Continuous infusion of sedative agents and clinical assessment of the level of sedation with BIS monitoring (index grou
2. Daily interruption of sedative infusions (index group 2)
3. Continuous infusion of sedative agents and clinical assessment of the level of sedation (reference group).
Sponsors
Academisch Medisch Centrum Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Consecutive ICU patients who are 18 years or older; 2. Patients who are sedated for less than 24 hours; 3. Patients who are expected to need sedation for at least another day.
Exclusion criteria
Exclusion criteria: 1. Patients who have been transferred from another ICU where sedative agents have been administered for more than 24 hours; 2. Patients with a decreased level of consciousness (defined as a Glasgow Coma Scale score of 12 or lower immediately before sedatives were administrated), will also be excluded; 3. Patients with an acute cerebral disease in whom the level of consciousness may decrease during admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of ICU stay, which is used as an inverse indicator of patient safety. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The duration of mechanical ventilation; 2. The number and type of accidentally removed catheters; 3. The use and type of additional diagnostic tests to evaluate possible oversedation; 4. The number of re-admissions to the ICU; 5. The length of hospital stay; 6. The score on the questionnaire on stressful events (Rotondi); 7. Cumulative survival from admission to the ICU until three months; 8. Direct, medical costs of used health care resources and indirect, non-medical costs of lost productivity. | — |
Contacts
Public ContactM.B. Vroom
Academic Medical Center (AMC), Intensive Care Adults (C3-423), P.O. Box 22660
Outcome results
None listed