Bronchopulmonary dysplasia
Conditions
Interventions
Spirometry, multiple breath washout and MRI
Sponsors
Erasmus MC- Sophia Children's Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosis of BPD according to the NHI criteria, aged between 6-10 years, will have/has a CT scan planned within 6 months of this research, informed consent by parents (and patient).
Exclusion criteria
Exclusion criteria: Inability to undergo MRI, inability to follow instructions in the MRI, current severe lung infection (symptoms of respiratory distress, severe coughing, antibiotic use), chronic oxygen use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes of this study are the pulmonary MR findings. All scans will be evaluated on changes in ventilation, inflammation, perfusion and structure. All data will be compared to the spirometry, LCI and MRI of two control groups: 1) premature non-BPD patients (born before <32 weeks without the diagnosis of BPD) 2) healthy volunteers. | — |
Secondary
| Measure | Time frame |
|---|---|
| A qualitative and feasibility check of all MRIs will be done. Furthermore, all the MRI findings will be compared to the spirometry and multiple breath washout measurements and a clinically ordered pulmonary CT made within six months of the research MRI. | — |
Contacts
Public ContactH.A.W.M. Tiddens
Erasmus Medical Center, Sophia Children’s Hospital Rotterdam, Department of Pediatric Pulmonology, Dr. Molewaterplein 60
Outcome results
None listed