Complex Regional Pain Syndrome type I (CRPS type I) Complex Regionaal Pijn Syndroom type I (CRPS type I)
Conditions
Interventions
Patients are randomised into 3 groups.
Admissions will take place in week 1 and 4 or week 1 and 13 of the study. All patients are admitted twice for 5 days, during which they will receive intravenous
Sponsors
Leiden University Medical Center (LUMC), Department of Anesthesiology
Eligibility
Inclusion criteria
Inclusion criteria: 1. CRPS type I diagnosis according to the IASP-criteria; 2. NRS spontaneous pain score of 5 or higher; 3. Age is between 18 and 70 years; 4. Patients must give a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are not able to give informed consent; 2. Patients suffering from other syndromes/diseases interfering with pain ratings; 3. Patients who previous have had ketamine continuous infusion; 4. Patients with co-morbidity such as: kidney disease, severe liver disease, nerve damage in the affected area, increased intracranial pressure, infectious disease, epilepsy, a psychiatric illness, thyroid disease, cancer, cardiac disease, pulmonary disease, severe or uncontrolled hypertension, aneurysm, glaucoma, history of cerebral vascular accident (CVA) < 1 year; 5. Patients who are pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Pain scores (NRS) - Allocation scores patients, whether they received S(+)-ketamine or placebo. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Occurence of side effects - Presence of CRPS type I diagnosis after treatment. | — |
Contacts
Public ContactI.M. Noppers
Leiden University Medical Center (LUMC) Department of Anaesthesiology P.O. Box 9600
Outcome results
None listed